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De novo design of cysteine proteases - Nature
Reported by Nature.com | October 14, 2026, 10:55 pm
De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.
<li>Radzicka, A. & Wolfenden, R. Rates of uncatalyzed peptide bond hydrolysis in neutral solution and the transition state affinities of proteases. J. Am. Chem. Soc.118, 61056109 (1996).
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